FIELD: medicine.
SUBSTANCE: method provides target modification of virulent properties of influenza virus by genetic modification of caspase and granzyme viral proteolysis sites. There is also described application of such genetically modified influenza virus as vaccines and therapeutic agents, translation and expression vectors of biologically active genetic elements, polypeptides and fragments thereof in an organism-recipient for metabolism targeting in bodies and tissues and as agents for selective elimination of damaged and tumour cells in an organism. The invention can be used in medicine.
EFFECT: well-directed attenuation or enhancement of viral virulence.
11 cl, 4 dwg, 2 tbl, 7 ex
