ANTAGONISTS CDK2 AS ANTAGONISTS OF SHORT FORM OF C-MAF TRANSCRIPTION FACTOR FOR GLAUCOMA TREATMENT Russian patent published in 2009 - IPC A61K31/52 A61F9/00 A61K31/404 A61P27/06

Abstract RU 2370267 C2

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to experimental ophthalmology, and can be applied for suppression of positive regulation of short form of c-Maf transcription factor in processed with steroids or transforming growth factor β2 (TGF β2) cells of trabecular net. For this purpose introduced is antagonist c-Maf, also possessing inhibiting activity with respect to cyclin-dependent kinase cdk2, for instance purvalanol A.

EFFECT: invention explains mechanism and possible new approach to treatment of primary open-angle and steroid glaucoma.

4 cl, 1 tbl, 7 ex, 3 dwg

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RU 2 370 267 C2

Authors

Shepard Allan R.

Dzhejkobson Nasrin

Klark Ehbbot F.

Dates

2009-10-20—Published

2004-12-21—Filed