MEDIATED PHKi INHIBITION OF Rho-KINASE FOR TREATING OPHTHALMIC DISORDERS Russian patent published in 2011 - IPC A61K31/7084 C12N15/113 C07H21/04 A61P27/02 

Abstract RU 2432165 C2

FIELD: medicine.

SUBSTANCE: invention refers to medicine, and concerns mediated PHKi inhibition of RHO-kinase for treating ophthalmic disorders. The substance of the invention involves RNA-interference for mRNA Rho-kinase expression inhibition for treating patients with ophthalmic disorders, especially for treating intraocular pressure, eye hypertension and glaucoma The mRNA Rho-kinase targets include gene ROCK 1 mRNA.

EFFECT: creation of the agent exhibiting improved properties.

56 cl, 2 ex, 4 dwg, 1 tbl

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RU 2 432 165 C2

Authors

Chatterton Dzhon E.

Klark Ehbbot F.

Dates

2011-10-27Published

2006-12-19Filed