CONDENSED PYRIDINE DERIVATIVES APPLICABLE AS ANTAGONISTS OF ADENOSINE RECEPTOR A Russian patent published in 2009 - IPC C07D471/04 C07D213/73 A61K31/437 A61K31/4427 A61P29/00 A61P11/00 A61P9/00 A61P3/00 A61P37/00 

FIELD: pharmacology.

SUBSTANCE: invention concerns compounds of formula (I) , where A is optionally substituted monocyclic aryl and heteroaryl group, B is optionally substituted monocyclic nitrogen-containing heterocyclic group, and either a) R¹ is hydrogen atom and R² is group selected out of -NH₂ and optionally substituted alkinyl group, or b) R², R¹ and -NH- group with linked R¹ form fragment selected out of fragments of formulae , , and , where R^a is selected out of hydrogen atom and group selected out of optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, -OR³, where R³ is independently selected out of group including hydrogen atom and lower alkyl or cycloalkyl groups, R^b is selected out of hydrogen atom and group selected out of optionally substituted alkyl or optionally substituted cycloalkyl group; application of claimed compounds in medicine obtainment for treatment of pathological states or diseases, the course of which is alleviated by antagonistic effect on adenosine receptor A_2B, and pharmaceutical composition with antagonistic effect on adenosine receptor A_2B.

EFFECT: compounds applicable in treatment of such diseases as asthma, bronchostenosis, allergic diseases, hypertension, atherosclerosis, reperfusion injury, myocardial ischemia, retinopathy, inflammation, gastrointestinal disorders related to cell proliferation, diabetes and/or autoimmune diseases.

26 cl, 49 ex, 2 tbl