METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTIONS Russian patent published in 2018 - IPC A61K31/4015 A61P25/28 

FIELD: medicine.

SUBSTANCE: group of inventions relates to medicine, namely to neurology and psychiatry, and can be used for treating central nervous system (CNS) disorders with cognitive impairment in a subject in need or at risk thereof. Wherein the CNS disorder is an amnestic mild cognitive impairment, dementia, Alzheimer's disease (AD), prodromal AD, post traumatic stress disorder (PTSD), schizophrenia, amyotrphic lateral sclerosis (ALS) and cancer-therapy-related cognitive impairment. Methods for treating, delaying or slowing the progression of central nervous system (CNS) disorders with cognitive impairment, as well as reducing the rate of decline of cognitive function in said condition, comprising the step of administering to said subject a levetiracetam or a pharmaceutically acceptable salt thereof in an amount of 125-250 mg per day. Also provided are pharmaceutical compositions for oral administration once a day for implementing the methods, comprising 125-250 mg of a levetiracetam or a pharmaceutically acceptable salt thereof, wherein a levetiracetam or a pharmaceutically acceptable salt thereof is in a form suitable for sustained release.

EFFECT: group of inventions provides improvement or normalization of cognitive functions in a subject with a CNS disorder, as well as preventing or slowing the progression of said CNS disorder with cognitive impairment.

7 cl, 28 dwg, 6 tbl, 3 ex