METHOD OF TREATING PATIENTS SUFFERING FROM COLORECTAL CANCER WITH LIVER METASTASES Russian patent published in 2009 - IPC A61K31/517 A61K31/282 A61K39/395 A61P35/00 

Abstract RU 2372089 C2

FIELD: medicine.

SUBSTANCE: invention concerns medicine, namely oncology and can be used in treatment of patients with colorectal cancer with multiple liver metastases. The first stage of treatment involves neoadjuvant oxalyplatine chemotherapy; in addition Tomudex is introduced in a dose 3 mg/m2 as a 24 hour continuous infusion. After termination of chemotherapy, biotherapy involves intra-arterial injection of Avastin in a dose 10 mg/kg of body weight within 2 hours, neoadjuvant intra-arterial chemotherapy and biotherapy totals in 4-6 courses. At the second stage 4 weeks after chemotherapy surgery is performed. The third stage involves 4-6 courses of adjuvant intra-arterial chemotherapy and biotherapy, as at the first stage.

EFFECT: invention allows increasing survival rate and life expectancy of the patients owing to improved respectability of metastases and lower toxicity of complex neoadjuvant and adjuvant intra-arterial chemotherapy and biotherapy.

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Authors

Lazarev Aleksandr Fedorovich

Patjutko Jurij Ivanovich

Shojkhet Jakov Naumovich

Kotel'Nikov Aleksej Gennad'Evich

Karpenko Andrej Anatol'Evich

Mamontov Konstantin Grigor'Evich

Igitov Vladimir Ivanovich

Belonozhka Anatolij Vasil'Evich

Ponomarenko Aleksej Alekseevich

Doroshenko Veronika Sergeevna

Porunov Vjacheslav Jur'Evich

Elinov Aleksandr Petrovich

Dates

2009-11-10Published

2007-12-26Filed