METHOD FOR COMBINED TREATMENT OF COLON CANCER Russian patent published in 2024 - IPC A61B17/00 A61K31/282 A61K31/519 A61K31/513 A61P35/00 

FIELD: medicine; oncology.

SUBSTANCE: invention can be used for combined treatment of colon cancer. Method involves conducting courses of preoperative chemotherapy, wherein oxaliplatin is administered in dose of 85 mg/m² intravenously drop-by-drop on day 1, duration of infusion is 2 hours, leucovorin in dose of 400 mg/m² intravenously drop-by-drop on day 1, duration of infusion is 2 hours, 5-fluorouracil in dose of 400 mg/m² intravenously in a stream on day 1, then in dose of 2,400 mg/m² at 1,200 mg/m²/day intravenously drop-by-drop in 1–2 days, duration of infusion is 46 hours. A break between the courses of chemotherapy is 2 weeks with the beginning of the next course on 15th day, wherein 8 courses of preoperative chemotherapy are carried out, followed by a radical surgical intervention.

EFFECT: use of the invention enables to achieve improved results of the combined treatment of colon cancer by increasing the rate of objective tumor responses, increasing the rate of radical resections (R0), increasing the completion rates of the chemotherapy courses, as well as improving the overall and recurrence-free survival rate of the patients.

1 cl, 1 ex