POLYPEPTIDE WITH ANTIVIRAL ACTIVITY, ITS PRODUCTION AND USE Russian patent published in 2009 - IPC C07K14/54 C12N15/24 C12N1/21 A61K38/20 

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, particularly to genetic engineering and it can be used in the biomedical industry to produce active medications of interleukin-29 (IL-29). Mutant forms of IL-29 (SEQ ID NO: 27, 29, 40, 41, 149 and 159) were offered with substitution of the cysteine residue in the position in accordance with position 171 of the aminoacid sequence of a mature protein of a wild type that are characterised by a correct formation of intramolecular disulfide bonds and accordingly they provide production of polypeptides with an antiviral activity as homogeneous medications at expression in the heterologous system.

EFFECT: vector structures and the host cells transformed by these structures for the expression of new versions of IL-29 are described.

15 cl, 37 tbl, 45 ex