FIELD: genetic engineering, medicine.
SUBSTANCE: invention relates to interleukin-20 receptors and can be used in treatment of inflammatory diseases. Soluble receptors for interleukin-20 (IL-20) are constructed consisting of two polypeptide subunits IL-20RA and IL-20RB. Subunits as components of IL-20 receptor are bound by disulfide bonds. Also, variants of IL-20 receptor are prepared wherein one subunit is fused with the constant region of immunoglobulin light chain, and another subunit is fused with the constant region of immunoglobulin heavy chain, and these chains of immunoglobulin are bound by a disulfide bond. Invention provides using new IL-20 receptors for down-regulation of IL-20.
EFFECT: valuable medicinal properties if IL-20 receptor.
9 cl, 8 dwg, 13 ex
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