FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to field of biochemistry and is intended for treatment or prevention of undesirable immune response. Claimed is novel soluble polypeptide CD83 (sCD83), containing SEQ ID NO:7, in which amino acid residues 12, 20, 92 and 114 represent cysteine, amino acid in position 85 represents serine and one or several of amino acids 1, 2, 3, 4 and 130 can be absent. Also claimed is nucleic acid, coding said sCD83, and application of said polypeptide in methods of treatment or prevention of transplant rejection or autoimmune diseases, such as type I diabetes, multiple sclerosis, Crohn's disease and ulcerative colitis.
EFFECT: invention makes it possible to increase stability and biological activity of sCD83 preparations.
15 cl, 39 dwg, 9 tbl, 10 ex
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