FIELD: biotechnologies.
SUBSTANCE: group of inventions relates to biotechnology. Disclosed is a mutant polypeptide containing or representing a fragment of adenylyl cyclase, corresponding to SEQ ID NO: 1, 7, 8 or 9. Also disclosed is recombinant polypeptide representing said polypeptide, which is additionally combined with one or more molecules of interest, capable of launch immune response. Disclosed is pharmaceutical composition containing one of above polypeptides.
EFFECT: group of inventions allows to induce t-cell and/or b-cell immune response in host organism for preventing or treating disease selected from neoplasia, cancer and infectious diseases caused by virus, retrovirus, bacterium of parasite or fungus.
21 cl, 16 dwg, 1 tbl, 1 ex
| Title |
Year |
Author |
Number |
| MODIFIED ADENYLATE CYCLASE BORDETELLA CONTAINING CD11b/CD18 INTERACTION DOMAIN OR CD11B/CD18 INTERACTION DOMAIN DEFICIENT, AND ITS APPLICATION |
2004 |
- Leklerk Klod
- Ehl'-Azami Ehl'-Idrissi Mokhammed
- Ladan Daniel'
- Bosh Sesil'
- Sebo Peter
- Louchka Irina
- Osichka Radim
|
RU2421241C2 |
| CyaA-CARRIED POLYPEPTIDE (VERSIONS) AND USE TO INDUCE BOTH THERAPEUTIC AND PROPHYLACTIC IMMUNE RESPONSES |
2012 |
- Eskerr Mishel
- Momo Mari
- Guber Ann
- Misseri Jolanda
|
RU2668795C2 |
| VECTORS FOR DELIVERY OF MOLECULES TO CD11b-EXPRESSING CELLS |
2001 |
- Leklerk Klod
- Germonpre P'Er
- Ladan Daniel'
- Gjuizo Nikol'
- Kelef Nadija
- Bosh Sesil'
- Fajoll' Katrin
- Ehl'-Azami Ehl'-Idrissi Mokhammed
|
RU2312143C2 |
| RECOMBINANT PROTEIN CARRYING HUMAN PAPILLOMA VIRUS EPITOPES, PROTEIN EMBEDDED ADENYLATECYCLASE OR ITS FRAGMENT, ITS THERAPEUTIC APPLICATION |
2005 |
- Preville Khav'Er-Ehdmond-Ehduard
- Leklerk Klod
- Ladant Daniel
- Timmerman Benedikt
|
RU2441022C2 |
| COMPOSITIONS CAUSING SPECIFIC RESPONSE OF CYTOTOXIC T-LYMPHOCYTES, INCLUDING LYMPH-ABLATIVE COMPOUND AND MOLECULE WHICH CONTAINS ANTIGEN SEQUENCES AND IS TARGETED AT SPECIALISED ANTIGEN-PRESENTING CELLS |
2007 |
- Previll' Ksav'E
- Timmerman Benedikt
|
RU2448729C2 |
| IMPROVED Bordetella pertussis VACCINES BASED ON MUTANT GLYCOSYLTRANSFERASES LPS |
2008 |
- Gertsen Jerun Jokhannes Gerardus
- Tommassen Jokhannes Petrus Marija
- Van Der Lej Peter Andre
|
RU2542667C2 |
| POLYPEPTIDES HAVING CELLULASE ACTIVITY |
2010 |
- Arnold Frensis Kh.
- Khajntselman Pit
|
RU2597289C2 |
| TRANSPOSASE POLYPEPTIDES AND USE THEREOF |
2016 |
- Belousova, Natalya
- Cooper, Laurence, J.
|
RU2735700C2 |
| METHOD FOR OBTAINING UP-REGULATING PD-L1 EXPRESSION, POLYPEPTIDES, A CONJUGATE, A FUSED POLYPEPTIDE, A COMPOSITION AND A COMBINATION TO PROVIDE UP-REGULATING EXPRESSION OF PD-L1 |
2016 |
- Lyuj, Yan-Ta
- Chan, Chia-Min
- Vej, Tsaj-Yan
|
RU2734169C2 |
| POLYPEPTIDE WITH ASPARTATE KINASE ACTIVITY AND USE THEREOF FOR PRODUCING AMINO ACIDS |
2021 |
- Zheng Ping
- Liu Jiao
- Wang Yu
- Zhou Wenjuan
- Sun Jibin
- Chen Jiuzhou
- Ma Yanhe
|
RU2821918C1 |
