MECHANO-ACTIVATED AMORPHOUS AND AMORPHOUS-CRYSTALLINE CALCIUM SALTS OF GLUCONIC ACID, COMPOSITIONS, METHODS OF PRODUCTION, PHARMACEUTICAL PREPARATIONS AND METHOD OF TREATMENT BASED ON SAID PREPARATIONS Russian patent published in 2009 - IPC C07C59/105 C07C51/00 C07C51/41 C07C51/43 A61K31/191 A61P3/02 A61P3/14 

FIELD: chemistry.

SUBSTANCE: crystalline calcium salt of gluconic acid or its compound with excipients is processed in grinding activator devices, or to a value of supplied specific energy of not more than 10.4 kJ/g and achieving amorphous-crystalline state, or to a value of specific energy of not less than 10.5 kJ/g and achieving amorphous state. The obtained substances are analysed using X-ray diffraction, infrared, NMR, EPR spectroscopy, mass- and chromatography-mass spectrometry and differential thermal analysis.

EFFECT: mechano-activated amorphous and amorphous-crystalline compounds and compositions are used as active compounds for making pharmaceutical preparations.

13 cl, 10 dwg, 12 ex