BIARYLOXYMETHYLARENE CARBOXYLIC ACIDS Russian patent published in 2009 - IPC C07C65/05 C07C65/21 C07C65/24 C07C205/34 C07D213/79 C07D277/20 C07D277/56 C07D307/68 C07D333/40 C07D405/06 A61K31/192 A61K31/341 A61K31/381 A61K31/4025 A61K31/426 A61K31/44 A61K31/4525 A61P3/10 

FIELD: chemistry.

SUBSTANCE: invention relates to new compounds of formula (I) , in which Ar is furanyl, thiophenyl, thiazolyl, pyridinyl; R¹ is independently chosen from a group consisting of hydrogen, lower alkyl, lower alkoxy, halogen and nitro; R² is independently chosen from a group consisting of hydrogen and halogen; R⁴ is hydroxyl or residue of pyrrolidine-2-carboxylic acid, piperidine-2-carboxylic acid or 1-aminocyclopentane carboxylic acid, bonded through a nitrogen atom of an amino acid residue; n is 0, 1, 2, 3, 4 or 5; m is 0, 1, 2, 3 or 4; p is 0, and s is 0, or to their pharmaceutically acceptable salts, under the condition that, the compound is not S-1- [5-(biphenyl-4-yloxymethyl)furan-2-carbonyl]pyrrolidin-2-carboxylic acid, 5-(biphenyl-4-yloxymethyl)furan-2-carboxylic acid, 3-(biphenyl-4-yloxymethyl)benzoic acid, 2-(biphenyl-3-yloxymethyl)benzoic acid, 4-(biphenyl-3-yloxymethyl)benzoic acid, 4-(biphenyl-4-yloxymethyl)benzoic acid, 5-(biphenyl-4-yloxymethyl)thiophene-2-carboxylic acid. Invention also relates to a pharmaceutical composition based on formula (I) compounds, which stimulates glycogen synthase activity.

EFFECT: wider range of use of the compounds.

27 cl, 34 ex, 8 dwg