DOUBLE NK1/NK3 ANTAGONISTS FOR TREATING SCHIZOPHRENIA Russian patent published in 2009 - IPC C07D213/00 C07D401/04 C07D409/04 A61K31/44 A61K31/4436 A61K31/4439 A61K31/444 A61P25/18 

FIELD: chemistry.

SUBSTANCE: present invention relates to use of compounds of formula (I) where R¹ is lower alkyl or halogen; R² is hydrogen or halogen; R³ is (CHR')_nOH, phenyl, possibly substituted with a -(CHR')_nOH group, or is a saturated, partially saturated or aromatic 5- or 6-member heterocyclic ring with one heteroatom, selected from a group which consists of -N(R⁴)-, -N=, -S- or -S(O)₂, where the rings are possibly substituted with a -(CHR')_nOH group; R' is hydrogen or a -(CH₂)_nOH, independent of the value of n; R⁴ is hydrogen, -S(O₂)-lower alkyl group or -C(O)-lower alkyl; X is -O-, -CH₂O-, -S- or a bond; n equals 1 or 2; or their pharmaceutically active acid addition salts for making medicine for treating schizophrenia, as well as to compounds of formula (I).

EFFECT: description is given of compounds which can be used in medicine.

8 cl, 16 ex, 1 tbl