PIPERIDINE DERIVATIVES Russian patent published in 2015 - IPC C07D401/14 C07D413/14 C07D417/14 C07D471/04 C07D487/04 C07D498/04 A61K31/4523 A61P25/28 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of structural formula

,

having Aβ42 secretion inhibiting activity. In formula I , hetaryl I is a five- or six-member heteroaryl group containing 1-3 heteroatoms selected from O, S or N, hetaryl II is a five- or six-member heteroaryl group containing 1-3 heteroatoms as defined above for hetaryl I, or is a bicyclic ring system containing 1-4 heteroatoms selected from S, O or N, where at least one ring is aromatic by nature, R¹ is C_1-7-alkyl, C_1-7-alkoxy, C_1-7-alkyl substituted with a halogen, or a halogen; R² is a halogen, C_1-7-alkyl, C_1-7-alkoxy, hydroxy, C_1-7-alkyl substituted with a halogen, C_1-7-alkyl substituted with a hydroxy, or benzo[1,3]dioxolyl or is -(CHR)_p-phenyl, optionally substituted with a halogen, C_1-7-alkyl, C_1-7-alkoxy, S(O)₂-C_1-7-alkyl, cyano, nitro, C_1-7-alkoxy substituted with a halogen, dimethylamino, -(CH₂)_p-NHC(O)O-C_1-7-alkyl or C_1-7-alkyl, substituted with a halogen. The values of radicals R, R³, R⁴, p, n, m, o are given in the claim.

EFFECT: invention relates to a method of producing said compounds, a medicinal agent containing said compounds and a method of treating Alzheimer's disease, cerebral amyloid angiopathy, Hereditary cerebral hemorrhage with amyloidosis-Dutch type (HCHWA-D), vascular dementia, dementia pugilistica or Down syndrome, associated with β amyloid activity.

21 cl, 283 ex