HUMANISED AHTH-CD4 ANTIBODY WITH IMMUNOSUPPRESSIVE PROPERTIES Russian patent published in 2009 - IPC C07K16/28 

FIELD: medicine.

SUBSTANCE: there is described a humanised CD4 antibody or its fragment able to activate regulatory CD25⁺CD4⁺ T-cells, which includes complementarity-determining regions (CDRs) of mice monoclonal CD4 B-F5antibody. There is offered medicinal composition for prevention and/or treatments of dysimmunity containing described antibody or its fragment in effective amount. There is disclosed method of treating a person that implies introduction of the offered composition to said person. The described antibody is able to activate regulatory CD25⁺CD4⁺ T-cells.

EFFECT: described antibody can be used for preparing immunosuppressive compositions.

16 cl, 14 dwg, 4 tbl, 4 ex