LIGAND GITR AND MOLECULES AND ANTIBODIES BOUND WITH LIGAND GITR, AND VERSIONS OF THEIR APPLICATION Russian patent published in 2009 - IPC C12N15/11 A61P37/00 

FIELD: medicine.

SUBSTANCE: according to the invention there is provided method of person's treatment in case of risk or made diagnosis of autoimmune disease or transplantate rejection, including antagonist GITR injection into the person, where antagonist prevents binding GITRL with GITR on excitatory T-cells. There is provided method of cell population proliferation inhibition, containing excitatory T-cells, including injection of antagonist GITR into the cell population, where antagonist prevents binding GITRL with GITR on excitatory T-cells. There is proposed the method of cell population suppression, containing excitatory T-cells, in the presence of CD4⁺ CD25⁺ suppressor cells, including injection of antagonist GITR into the cell population, where antagonist GITR prevents binding GITRL with GITR on excitatory T-cells. There is provided pharmaceutical composition, containing antagonist GITR and pharmaceutically acceptable carrier for autoimmune disorder treatment, inflammatory diseases and transplantate rejection, where antagonist GITR prevents binding GITRL with GITR on excitatory T-cells.

EFFECT: invention can be applied for treatment of disorders, appearing in the result of disarranged immune reactions.

16 cl, 33 dwg, 3 tbl, 16 ex