METHOD FOR REDUCTION OF OXIDISING INJURY (VERSIONS) Russian patent published in 2009 - IPC A61K38/00 A61P39/06 

Abstract RU 2376028 C2

FIELD: medicine.

SUBSTANCE: invention is related to medicine, namely to pharmacotherapy, and may be used to reduce oxidising injury in mammals, in remote organ or cell. For this purpose aromatic cationic peptides are introduced, which are selected from the group 2',6'-Dmt-D-Arg-Phe-Orn-NH2 (SS-05), 2',6'-Dmt-D-Cit-Phe-Lys-NH2 (SS-29), Phe-D-Arg-2',6'-Dmt-Lys-NH2 (SS-30), D-Arg-2',6'-Dmt-Lys-Phe-NH2 (SS-31) and 2',6'-Dmt-D-Arg-Phe-(2-aminoheptanoic acid)-MH2 (SS-32) in efficient amount.

EFFECT: invention expands arsenal of agents with antioxidant activity that are able to penetrate not only through blood-brain barrier and cell membranes, but also into mitochondria.

31 cl, 2 tbl, 20 ex, 17 dwg

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RU 2 376 028 C2

Authors

Szeto Khehzel Kh.

Dates

2009-12-20Published

2005-01-21Filed