STEREO-SELECTIVE SYNTHESIS OF AMINO ACIDS FOR PRODUCTION OF TUMOR IMAGE Russian patent published in 2009 - IPC C07C229/48 C07B59/00 C07F13/00 A61K51/04 A61K31/196 

Abstract RU 2376282 C2

FIELD: medicine.

SUBSTANCE: new pure syn-aminoacids of formulas I and II have ability of specific binding in biological system and may be used to produce image of tumor. II and I. In formulae I and II Y and Z are independently selected from group made of CH2 and (CR4R5)n, n=1, 2; R1-R3 are independently selected from group made of H and alkyl C1-C4; R4, R5 = H and R7 = 18F. Invention is related to method of synthesis of syn-aminoacids with formula II, which includes stages of ketone transformation into trans-spirit of formula I and transformation of produced trans-spirit into syn-aminoacid of formula II, and also to pharmaceutical composition for production of tumor image and method for production of tumor image.

EFFECT: improved efficiency of compounds and method of treatment.

12 cl, 1 tbl, 3 dwg, 3 ex

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RU 2 376 282 C2

Authors

Gudmen Mark M.

Ju Vejping

Dates

2009-12-20Published

2006-06-19Filed