METHOD OF PRODUCING RADIOACTIVE FLUORINE-LABELLED ORGANIC COMPOUND Russian patent published in 2011 - IPC C07C227/18 C07C227/20 C07C229/48 C07B59/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing a radioactive fluorine-labelled organic compound of formula (3). The method involves a step for splitting an ester of formula (1), where R¹ is a straight or branched C₁-C₁₀ alkyl and R² is a protecting group selected from straight or branched C₂-C₇ alkyloxycarbonyl groups, passed through and held in a reverse phase column containing filler with a structure in which C₂-C₁₈ alkyl groups are attached to a substrate by silicon. In order to split said ester, alkali solution is fed into the column, after which alkaline solution is discharged from the column to obtain a compound of formula (2), where X is sodium or potassium and R² is a protecting group selected from straight or branched C₂-C₇ alkyloxycarbonyl groups. At the next step, the protecting group R² of the compound of formula (2), obtained at the ester splitting step, is removed to obtain a compound of formula (3).

EFFECT: method enables to reduce the amount of nonradioactive impurities and obtain a compound of formula (3) with good output.

2 cl, 3 dwg, 5 tbl, 2 ex