METHOD OF PRODUCING RADIOACTIVE, FLUORINE-LABELLED ORGANIC COMPOUND Russian patent published in 2013 - IPC C07C227/16 C07B59/00 A61K51/00 C07C229/48 

FIELD: chemistry.

SUBSTANCE: disclosed is a method of producing a radioactive, fluorine-labelled organic compound of formula , involving a step of heating a compound of formula at temperature of 40-90°C (where R¹ denotes a linear or branched alkyl with 1-10 carbon atoms or an aromatic substitute; R² denotes a linear or a branched halogen-alkylsuphonic acid substitute with 1-10 carbon atoms, a linear or branched alkylsulphonic acid substitute with 1-10 carbon atoms, a fluorosulphonic acid substitute or an aromatic sulphonic acid substitute, and R³ denotes a protective group) while stirring in an inert organic solvent in the presence of a phase transfer catalyst, ¹⁸F ions and calcium ions for radioactive fluorine labelling, and concentration of the phase transfer catalyst in the inert organic solvent is not less than 70 mmol/l.

EFFECT: disclosed method improves output of radioactive fluorination.

5 cl, 43 ex, 5 tbl, 6 dwg