PROCESS OF OBTAINING PRECURSOR COMPOUNDS FOR RADIOACTIVE HALOGEN-TAGGED COMPOUNDS Russian patent published in 2012 - IPC C07C303/28 C07C303/44 C07C309/65 A61K51/00 C07B59/00 

FIELD: chemistry.

SUBSTANCE: invention relates to method of obtaining precursor compound of radioactive fluorine-tagged compound, of formula , which includes: stage of interaction, providing conditions for interaction of solution, which contains substance with the following chemical formula : where R1 represents protective group of carboxyl group, and R2 represents protective group of aminogroup together with base, selected from group, consisting of alkylamides, from primary to quaternary, with unbranched or branched chain with 1-10 carbon atoms, nitrogen-containing heterocyclic substances with 2-20 carbon atoms and nitrogen-containing heteroaromatic substances with 2-20 carbon atoms, and compound, reacting with OH-group of compound of chemical formula (1), with conversion into leaving group, selected from group, consisting of alkylsulfonic acid with unbranched or branched chain of 1-10 carbon atoms, haloalkylsulfonic acid with unbranched or branched chain of 1-9 carbon atoms, aromatic sulfonic acid and chloride of aromatic sulfonic acid; as well as stage of purification of reaction solution, obtained at the stage of interaction, to obtain practically individual stereoisomer of substance with the following chemical formula (2), where R1 represents protective group of carboxyl group, R2 represents protective group of amino group, and R3 represents leaving group.

EFFECT: elaborated is method of obtaining tagged precursor, convenient for obtaining amino acid, tagged with radioactive fluorine, used for positron-emission topography.

9 cl, 2 dwg, 1 ex