METHOD OF PRODUCING 1,1-1,6-HEXAMETHYLENE-3,3,3',3'-TETRAKIS(2-OXYETHYL)-BIS-UREA Russian patent published in 2009 - IPC C07C273/18 C07C273/16 C07C275/10 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing1,1-1,6-hexamethylene-3,3,3',3'-tetrakis(2-oxyethyl)-bis-urea, which can be used in medicine. The method involves reacting 1,6-hexamethylene diisocyanate with diethanolamine in an aqueous medium, where diethanolamine is taken in stoichiometric amount ranging from 1.001 to 1.01 and after synthesis, excess diethanolamine is removed on a cation exchange resin, which is added to the reaction mixture in amount ranging from 5 to 10% of the mass of initial components while stirring until pH of the reaction mixture falls to a value ranging from 7.0 to 7.2.

EFFECT: simplification of the method and increased output of the end product.

1 cl, 3 ex, 1 tbl