DERIVATIVES OF ISOTHIOUREA AND METHOD OF THEIR PRODUCTION, THEIR APPLICATION AND PHARMACEUTICAL COMPOSITION Russian patent published in 2009 - IPC C07D277/42 C07D513/04 A61K31/429 A61P29/00 A61P35/00 A61P37/00 

FIELD: medicine.

SUBSTANCE: invention is related to derivatives of isothiourea of formula I, including their pharmaceutically acceptable salts, which possess properties of antagonist CXCR4. In compounds of formula I , where R¹ means remainder of formula (a) , (b) or (c) , R² means -(CR₂₂R₂₃)_1-3-, R₃ and R₈ each means S, R₄ and R₅ each independently means C₃-C₁₂cycloalkyl, C₁-C₁₂alkyl or saturated C₈-C₁₂ polycyclic hydrocarbon remainder, such as adamantine, non-substituted phenyl or non-substituted benzyl unnecessarily substituted with group R₂₅, R₆ means H or C₁-C₆alkyl, R₇ means CH, R₉ means direct connection or -(CR₂₂R₂₃)_1-2-, R₁₀-R₁₅ each means H, R₁₆-R₂₃ each independently means H, C₁-C₆alkyl, or R₂₀ and R₂₁ together with carbon atoms, to which they are connected, create a benzene ring, and R₂₅ has one of values given above for R₁₆-R₂₃.

EFFECT: improved method for production of derivatives of isothiourea.

5 cl, 1 tbl, 24 ex