ISOLATED MOLECULE OF NUCLEIC ACID, WHICH CODES FUSED POLYPEPTIDE THAT IS ABLE TO BIND VESSEL ENDOTHELIOCYTES GROWTH FACTOR (VEGF), FUSED POLYPEPTIDE, COPIED EXPRESSIVE VECTOR, METHOD FOR PRODUCTION OF FUSED POLYPEPTIDE, TRAP OF VEGF, PHARMACEUTICAL COMPOSITION, METHOD FOR TREATMENT AND SET FOR TREATMENT OF VEGF-MEDIATED DISEASE OR CONDITION Russian patent published in 2009 - IPC C12N15/12 C07K14/71 C12N15/62 C12N15/63 C12N15/86 C12P21/02 A61K38/17 A61P9/00 

FIELD: medicine.

SUBSTANCE: invention is related to nucleic acids and multidomain proteins, which are able to bind vessel endotheliocyte growth factor (VEGF), and may be used in medicine. Recombinant method is used to produce polypeptide, which consists of component (R1R2)_X and, unnecessarily, multidomain component (MC), which represents aminoacid sequence with length from 1 to 200 of amino acids, having at least one remainder of cysteine, where X≥1, R1 means antibody-like (Ig) domain 2 of VEGF receptor Llt-1, and R2 means Ig-domain 3 of VEGF receptor Flk-1. Produced fused polypeptide does not contain multidomain component in case, when X=2, and in case when X=1, multidomain component represents aminoacid sequence with length from 1 to 15 amino acids. Produced polypeptide is used in composition of pharmaceutical compound for VEGF-mediated disease or condition.

EFFECT: invention makes it possible to produce highly efficient trap of VEGF, special structure of which is suitable for local introduction into specific organs, tissues or cells.

16 cl, 3 tbl, 7 ex