FIELD: chemistry.
SUBSTANCE: invention relates to organic chemistry and specifically to a heterocyclic compound of formula (I), where V1 is CR1, V2 is N, V3 is CR3, and V4 is CR4; X is a bond or C1 alkylene; Y is O; A is
,
where each n independently takes values of 0, 1 or 2; and each R8a is independently H, F, Cl, Br, cyano or C1-4 haloalkyl; B is -NR7R7a; R1 is C1-3 alkyl, C6-10 aryl-C1-3-alkyl, C6-10 aryl-(CH2)p-G-(CH2)m-, pyridyl-(CH2)p-G-(CH2)m- or C6 cycloalkyl-(CH2)p-G-(CH2)m-, where each G is O or S, where each p is 0, and m is 1, 2 or 3; or where each of C6-10 aryl-(CH2)p-G-(CH2)m-, pyridyl-(CH2)p-G-(CH2)m- and C6 cycloalkyl-(CH2)p-G-(CH2)m- is optionally substituted with one or two F, Cl, Br, C2-6 alkynyl, C1-6 alkoxy or cyano; where C6-10 aryl-C1-3-alkyl is unsubstituted or substituted with F, Cl, Br; R3 is C1-3 alkyl; R4 is H; each R7 independently represents H, C1-6 alkyl or C1-6 alkoxy-C1-4-alkyl; and each R7a is independently C1-6 alkyl, C1-6 alkoxy-C1-4-alkyl, C6-10 aryl-C1-4-alkyl, C1-9 heteroaryl-C1-4-alkyl, C2-10 heterocyclyl-C1-4-alkyl or C3-10 cycloalkyl-C1-4-alkyl; where C1-9 heteroaryl is selected from imidazole, tetrazole and indole; and C2-10 heterocyclyl is selected from morpholine, piperidine and tetrahydrofuran; or R7 and R7a, together with the nitrogen atom to which they are bonded, optionally form a substituted or unsubstituted 3–8-member ring which is selected from morpholine, thiomorpholine, piperazine, piperidine, pyrrolidinyl, pyrrole and pyrazole; where substituted 3–8-member ring is substituted with 1 or 2 substitutes selected from oxo, C1-3 alkyl, hydroxyl and C2-3 alkynyl.
EFFECT: technical result is obtaining novel pyrimidinone derivatives, useful for preventing, regulating or treating tissue or organ fibrosis or for treating the severity of tissue or organ fibrosis in the patient's body.
10 cl, 2 tbl, 72 ex
| Title | Year | Author | Number |
|---|---|---|---|
| NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES AND USE THEREOF IN MEDICINAL PREPARATIONS | 2014 |
|
RU2694254C1 |
| MACROCYCLIC COMPOUNDS AS TRK KINASE INHIBITORS | 2019 |
|
RU2778294C2 |
| PROCESSES FOR PREPARING DIHYDROPYRIMIDINE DERIVATIVES AND INTERMEDIATE COMPOUNDS THEREOF | 2014 |
|
RU2688193C1 |
| FIVE-MEMBERED HETEROCYCLES AS INHIBITORS OF LEUKOCYTE ADHESION AND VLA-4 ANTAGONISTS | 1997 |
|
RU2229296C2 |
| 3,4-DIHYDROISOQUINOLINE COMPOUND AND USE THEREOF | 2021 |
|
RU2825312C1 |
| PPAR-SUPPORTING COMPOUNDS FOR TREATING METABOLIC DISEASES | 2014 |
|
RU2687490C2 |
| NEW ANTHELMINTIC QUINOLINE-3-CARBOXAMIDE DERIVATIVES | 2017 |
|
RU2772283C2 |
| NEW ANTIMICROBIAL AGENTS | 2009 |
|
RU2522582C2 |
| PYRIMIDO[5,4-B]INDOLIZINE OR PYRIMIDO[5,4-B]PYRROLIZINE COMPOUND, METHOD FOR PRODUCTION THEREOF AND USE THEREOF | 2017 |
|
RU2721774C1 |
| NEW FIVE-MEMBER HETEROCYCLES, THEIR PREPARING, THEIR APPLYING AND PHARMACEUTICAL PREPARATIONS COMPRISING THEREOF | 1998 |
|
RU2240326C2 |
