Show metadata Hide metadata

(19)

(11)

2 684 635

(13)

(51)

IPC

C07D471/04(2006-01-01)

A61K31/437(2006-01-01)

A61K31/4427(2006-01-01)

A61K31/5377(2006-01-01)

A61P3/00(2006-01-01)

A61P9/00(2006-01-01)

A61P25/28(2006-01-01)

A61P27/00(2006-01-01)

A61P29/00(2006-01-01)

A61P35/00(2006-01-01)

A61P37/00(2006-01-01)

(21) (22)

Application

2016126656, 2014-12-08

(24)

Start date

2014-12-08

(22)

Actual filing date

2014-12-08

(45)

Published

2019-04-11

(72)

Inventor

Dzhekson Viktoriya ElizabetKroplin BorisLoue Martin AleksanderPorter Dzhon Robert

(73)

Holder

Ucb Biopharma Sprl

TETRAHYDROIMIDAZOPYRIDINE DERIVATIVES AS TNF ACTIVITY MODULATORS Russian patent published in 2019 - IPC C07D471/04 A61K31/437 A61K31/4427 A61K31/5377 A61P3/00 A61P9/00 A61P25/28 A61P27/00 A61P29/00 A61P35/00 A61P37/00

Abstract RU 2684635 C1

FIELD: organic chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to a heterocyclic compound selected from 4-{1-[(2,5-dichlorophenyl)methyl]-2-methyl-6,7-dihydro-4H-imidazo[4,5-c]pyridin-5-yl}-N,N-dimethylpyridine-2-amine and {1-[(2,5-dichlorophenyl)methyl]-2-(pyridin-3-yloxymethyl)-6,7-dihydro-4H-imidazo-[4,5-c]pyridin-5-yl}(morpholin-4-yl)methanone. Invention also relates to a pharmaceutical composition based on said compound, use of said compound and a method of treating rheumatoid arthritis and Crohn's disease.

EFFECT: technical result is obtaining novel heterocyclic compounds having properties of a TNFα activity modulator.

4 cl

Similar patents RU2684635C1

Title	Year	Author	Number
TRIAZOLOPYRIDAZINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Brukings Daniel Kristofer	RU2677698C1
IMIDAZOTHIAZOLE DERIVATIVES AS TNF ACTIVITY MODULATORS	2014	Aleksander Rikki Piter Ali Mezkher Khussejn Braun Dzhulien Alister Dzhekson Viktoriya Elizabet	RU2683940C1
BENZOTRIAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Brukings Daniel Kristofer Kroplin Boris	RU2677696C1
IMIDAZOPYRIMIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Ali Mezkher Khussejn Brukings Daniel Kristofer Braun Dzhulien Alister Dzhekson Viktoriya Elizabet Kroplin Boris Porter Dzhon Robert	RU2691629C1
PYRAZOLOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Brukings Daniel Kristofer Dzhekson Viktoriya Elizabet Kroplin Boris	RU2684641C1
TRIAZOLOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Brukings Daniel Kristofer Dzhekson Viktoriya Elizabet	RU2677697C1
TETRAHYDROIMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Defej Sabine Kher Yag Paul Dzhekson Viktoriya Elizabet Dzhonson Dzhejms Endryu Kroplin Boris Porter Dzhon Robert	RU2696270C1
CONDENSED BICYCLIC HETEROAROMATIC DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Aleksander Rikki Piter Foulks Gregori Khatchings Martin Klajv Dzhekson Viktoriya Elizabet Kroplin Boris Ryuberson Dzhejms Tomas Ruk Sera Margaret Chzhu Chzhoanin	RU2685234C1
IMIDAZOPYRIDAZINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Ali Mezkher Khussejn Brukings Daniel Kristofer Braun Dzhulien Alister Khatchings Martin Klajv Dzhekson Viktoriya Elizabet Kroplin Boris Porter Dzhon Robert Kuinsi Dzhoanna Rejchel	RU2679609C1
IMIDAZOPYRIDINE DERIVATIVES AS MODULATORS OF TNF ACTIVITY	2014	Delini Mikhael Lui Rober Kher Yag Paul Dzhekson Viktoriya Elizabet Kroplin Boris Lekomt Faben Klod Porter Dzhon Robert	RU2678305C1

RU 2 684 635 C1

Authors

Dzhekson Viktoriya Elizabet

Kroplin Boris

Loue Martin Aleksander

Porter Dzhon Robert

Dates

2019-04-11—Published

2014-12-08—Filed