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(19)

(11)

2 685 234

(13)

(51)

IPC

C07D215/14(2006-01-01)

C07D217/20(2006-01-01)

C07D237/28(2006-01-01)

C07D239/74(2006-01-01)

C07D241/44(2006-01-01)

A61K31/47(2006-01-01)

A61K31/472(2006-01-01)

A61K31/498(2006-01-01)

A61K31/502(2006-01-01)

A61K31/506(2006-01-01)

A61K31/517(2006-01-01)

A61P3/00(2006-01-01)

A61P9/00(2006-01-01)

A61P25/28(2006-01-01)

A61P27/00(2006-01-01)

A61P29/00(2006-01-01)

A61P35/00(2006-01-01)

A61P37/00(2006-01-01)

(21) (22)

Application

2016127441, 2014-12-08

(24)

Start date

2014-12-08

(22)

Actual filing date

2014-12-08

(45)

Published

2019-04-17

(72)

Inventor

Aleksander Rikki PiterFoulks GregoriKhatchings Martin KlajvDzhekson Viktoriya ElizabetKroplin BorisRyuberson Dzhejms TomasRuk Sera MargaretChzhu Chzhoanin

(73)

Holder

Ucb Biopharma Sprl

CONDENSED BICYCLIC HETEROAROMATIC DERIVATIVES AS MODULATORS OF TNF ACTIVITY Russian patent published in 2019 - IPC C07D215/14 C07D217/20 C07D237/28 C07D239/74 C07D241/44 A61K31/47 A61K31/472 A61K31/498 A61K31/502 A61K31/506 A61K31/517 A61P3/00 A61P9/00 A61P25/28 A61P27/00 A61P29/00 A61P35/00 A61P37/00

Abstract RU 2685234 C1

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to a heterocyclic compound of formula (IIB) or a pharmaceutically acceptable salt thereof, where q equals 1; A denotes CR²; G is a pyridazinyl ring residue; E denotes -O-, -CH₂- or -CH(CH₃)-; Q is -CH₂-; Z is hydrogen; V is N; R² denotes hydrogen; R¹⁵ denotes hydrogen, methyl or difluoromethoxy group; R¹⁶ denotes hydrogen; R²¹ denotes hydroxy(C₁-C₆)alkyl; and R²³ denotes hydrogen. Invention also relates to a pharmaceutical composition based on a compound of formula (IIB), use of the compound of formula (IIB) and a method of treating and/or preventing rheumatoid arthritis or Crohn's disease. (IIB).

EFFECT: technical result is obtaining novel heterocyclic compounds having properties of a TNFα signal transmission modulator.

7 cl, 12 ex

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RU 2 685 234 C1

Authors

Aleksander Rikki Piter

Foulks Gregori

Khatchings Martin Klajv

Dzhekson Viktoriya Elizabet

Kroplin Boris

Ryuberson Dzhejms Tomas

Ruk Sera Margaret

Chzhu Chzhoanin

Dates

2019-04-17—Published

2014-12-08—Filed