PYRIDINE-2-CARBOXAMIDE DERIVATIVES AS mGluR5 ANTAGONISTS Russian patent published in 2011 - IPC C07D213/81 C07D401/12 C07D401/14 C07D417/14 A61K31/4436 A61K31/4439 A61K31/444 A61K31/506 A61P25/00 

FIELD: chemistry.

SUBSTANCE: present invention relates to compounds of formula (I), where R¹ denotes a 5- or 6-member ring of formulae

(II) or (III), respectively: R² denotes H, C₁-C₇-alkyl, C₃-C₆-cycloalkyl or -(CH₂)_m,-R^a; R³ denotes aryl or heteroaryl, which can be substituted with CN, Cl, F, Br, CF₃, CHF₂, C₃-C₆-cycloalkyl or denotes heteroaryl which can be possibly substituted with C₁-C₇-alkyl; R⁴ denotes H, -OH, Cl, F, Br, CN, -CHF₂, CF₃, C₁-C₇-alkyl, C₃-C₆-cycloalkyl or -(CH₂)_m-R^e; R⁵ denotes C₁-C₇-alkyl, -(CH₂)_n-O-R^f, or -(CH₂)_n-R^e; R^a denotes -OH; R^e denotes -OH; R^f denotes C₁-C₇-alkyl; m equals 1-4; n equals 2-6; and pharmaceutically acceptable salts thereof. The invention also relates to a medicinal agent containing said derivatives, use thereof in preparing medicinal agents suitable for treating diseases of the central nervous system.

EFFECT: novel compounds suitable for treating diseases of the central nervous system are obtained and described.

29 cl, 111 ex