COMPOSITION FOR FLUORESCENT DIAGNOSTICS AND PHOTODYNAMIC THERAPY Russian patent published in 2010 - IPC A61K9/06 A61N5/00 

Abstract RU 2379026 C2

FIELD: medicine.

SUBSTANCE: invention relates to medicine and concerns pharmacological composition for fluorescent diagnostics (FD) and photodynamic therapy (PDT) with application of prosensibiliser -5-aminolevulinic acid (ALA) hydrochloride. Composition for fluorescent diagnostics and photodynamic therapy includes 5-aminolevulinic acid hydrochloride as active substance, gel-forming polymer-hydroxyethylcellulose and water. Composition additionally contains plasticiser and organic additive. Composition can also include surface-active substance - block-copolymer of ethylene oxide and propylene oxide in amount 2.5-5.0 % wt, as well as preservative in amount 0.05-0.3 % wt. Claimed composition can be efficiently applied for FD and PDT.

EFFECT: invention insures creation of stable in storing gel composition, which contains ALA as active component in amount not less than 5% and water gel as base.

6 cl, 27 ex, 4 tbl, 1 dwg

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RU 2 379 026 C2

Authors

Vorozhtsov Georgij Nikolaevich

Dorozhkina Galina Nikolaevna

Kazachkina Natal'Ja Ivanovna

Kuz'Min Sergej Georgievich

Luk'Janets Evgenij Antonovich

Negrimovskij Vladimir Mikhajlovich

Osikov Nikolaj Vladimirovich

Pankratov Andrej Aleksandrovich

Sakharova Natal'Ja Aleksandrovna

Chissov Valerij Ivanovich

Jakubovskaja Raisa Ivanovna

Avramenko Grigorij Vladimirovich

Dates

2010-01-20Published

2008-04-15Filed