FIELD: medicine.
SUBSTANCE: invention relates to medicine and concerns pharmacological composition for fluorescent diagnostics (FD) and photodynamic therapy (PDT) with application of prosensibiliser -5-aminolevulinic acid (ALA) hydrochloride. Composition for fluorescent diagnostics and photodynamic therapy includes 5-aminolevulinic acid hydrochloride as active substance, gel-forming polymer-hydroxyethylcellulose and water. Composition additionally contains plasticiser and organic additive. Composition can also include surface-active substance - block-copolymer of ethylene oxide and propylene oxide in amount 2.5-5.0 % wt, as well as preservative in amount 0.05-0.3 % wt. Claimed composition can be efficiently applied for FD and PDT.
EFFECT: invention insures creation of stable in storing gel composition, which contains ALA as active component in amount not less than 5% and water gel as base.
6 cl, 27 ex, 4 tbl, 1 dwg
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Authors
Dates
2010-01-20—Published
2008-04-15—Filed