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(19)

(11)

2 379 056

(13)

(51)

IPC

A61K39/395(2006-01-01)

C07K16/28(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2005120167/15, 2003-11-25

(24)

Start date

2003-11-25

(22)

Actual filing date

2003-11-25

(45)

Published

2010-01-20

(72)

Inventor

Mark NasoffKvinn L. DeveroksDebora A. KniPedro Asa-BlankGarret M. KhehmptonKlaus Vagner

(73)

Holder

Ajrm Lls

METHODS AND COMPOSITIONS FOR INDUCING APOPTOSIS OF CANCER CELLS Russian patent published in 2010 - IPC A61K39/395 C07K16/28 A61P35/00

Abstract RU 2379056 C2

FIELD: medicine.

SUBSTANCE: invention refers to medicine and concerns methods and compositions for inducing apoptosis of cancer cells. Substance of the invention includes the modified antibodies-DR-5 agonists which in combination with apoptosis-inducing agents, synergetically induce apoptosis of cancer cells.

EFFECT: intensified antineoplastic activity.

19 cl, 51 ex, 2 tbl, 35 dwg

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RU 2 379 056 C2

Authors

Mark Nasoff

Kvinn L. Deveroks

Debora A. Kni

Pedro Asa-Blank

Garret M. Khehmpton

Klaus Vagner

Dates

2010-01-20—Published

2003-11-25—Filed