BETA-LACTAMASE INHIBITORS Russian patent published in 2019 - IPC C07F5/02 A61K31/69 A61P31/04 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (II) or a pharmaceutically acceptable salt thereof

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In formula (II): M is hydrogen, -CN, -SO₂-N(R⁴R⁵), -N(R⁴)-C(O)-N(R⁴R⁵), -N(R⁴)-SO₂-R⁵, -C(O)-R⁴, -C(O)-N(R⁴R⁵), or 6-member heteroaryl; R¹ and R² are hydrogen; each n independently has values of 1, 2 or 3; X¹ is -OR⁴; Z is >C = O; R³ is R³¹, -R³⁰OC(O)R³¹ or -R³⁰OC(O)OR³¹; R³⁰ is -CH₂- or -CH(CH₃) -; R³¹ is C₁-C₁₂alkyl, C₁-C₆alkoxy(C₁-C₆alkyl), C₃-C₈cycloalkyl, C₃-C₈heterocycloalkyl, 6-member aryl (optionally substituted with fluorine), C₁-C₆alkyl(C₃-C₈cycloalkyl) or C₁-C₆alkyl (C₃-C₈heterocycloalkyl) (optionally substituted C₁-C₆alkyl); R^a, R^b and R^c independently represent hydrogen, fluorine or C₁-C₆alkyl; R^d is hydrogen; R⁴ and R⁵ independently represent hydrogen or C₁-C₆alkyl. Also disclosed are a number of specific compounds, a pharmaceutical composition, a method of treating a bacterial infection.

EFFECT: disclosed compounds modulate the activity of beta-lactamases and are useful in treating bacterial infections in combination with a beta-lactam antibiotic.

20 cl, 4 tbl, 171 ex

формула - formula