FIELD: chemistry.
SUBSTANCE: invention relates to improved method of obtaining silodosin of formula: 
(3). Method involves mixing a new compound 3-{7-cyano-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino]propyl]-2,3-dihydro-1H-indol-1-yl}propylbenzoate with oxalic acid to obtain a corresponding oxalate with subsequent hydrolysis thereof, resulting in formation of a new compound 1-(3-hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino]propyl]-2,3-dihydro-1H-indole-7-carbonitrile and hydrolysis thereof to obtain the target compound. Methods of obtaining new intermediate compounds are described.
EFFECT: improved method of producing indoline.
12 cl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DERIVATIVES OF INDOLE AND PHARMACEUTICAL COMPOSITION COMPRISING THEREOF | 1999 |
|
RU2212404C2 |
| ARYL-SUBSTITUTED CARBOXAMIDE DERIVATIVES AS CALCIUM OR SODIUM CHANNEL BLOCKERS | 2010 |
|
RU2575168C2 |
| N-(2-CYANO HETEROCYCLYL)PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | 2014 |
|
RU2669922C2 |
| PYRROLOPYRIDINONE DERIVATIVES AS TTX-S BLOCKERS | 2013 |
|
RU2646754C2 |
| PYRAZOLOPYRIDINE DERIVATIVES AS TTX-S BLOCKERS | 2013 |
|
RU2652117C2 |
| NEW BIPHENYL COMPOUND OR ITS SALT | 2018 |
|
RU2765152C2 |
| CYCLOALKYL NITRILE PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS | 2014 |
|
RU2655380C2 |
| NEW BIPHENYL COMPOUND OR ITS SALT | 2016 |
|
RU2726622C2 |
| DERIVATIVES OF NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS, METHODS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHODS FOR TREATMENT OF INFLAMMATORY DISEASES AND RESPIRATORY WAYS DISEASES | 2001 |
|
RU2265011C2 |
| HETEROCYCLIC COMPOUNDS AND METHODS OF APPLICATION | 2009 |
|
RU2525116C2 |
