ISOTOPE-LABELED PRODUCTION QUINOLINES, ACTING AS LIGANDS OF ADENOSINE RECEPTOR A Russian patent published in 2010 - IPC C07D215/54 C07D409/12 C07F7/22 A61K31/435 A61K51/04 A61P25/00 A61P43/00

Abstract RU 2379290 C2

FIELD: chemistry.

SUBSTANCE: invention relates to compounds with general formula (I) and its isomers, where R¹ is a hydrogen atom of an alkyl C_1-4 group with a straight or branched chain, or a phenyl group, thienyl group or furyl group, optionally substituted with one or more alkyl C_1-4 groups with a straight or branched chain, C_1-4 alkoxy groups with a straight or branched chain, or halogen atoms; R² is a hydrogen atom or an alkyl C_1-4 group with a straight or branched chain, or a phenyl, benzyl, thienyl or furyl group, optionally substituted with a methylenedioxy group, or one or more alkyl C_1-4 groups with a straight or branched chain, or C_1-4 alkoxy-, hydroxyl-, trifluoromethyl- or cyano-group with a straight or branched chain, or halogen atoms, as well as to a method of producing said compound. The invention also relates to new intermediates with general formula (II) and their production.

EFFECT: radioligands A₃ with antagonistic action are obtained and described, labeled with iodine isotopes with mass number 125, which have high specific activity.

16 cl, 3 ex, 2 tbl, 1 dwg

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RU 2 379 290 C2

Authors

Timari Geza

Boehr Kinga

Tot Geza

Tembeli Chaba

Dates

2010-01-20—Published

2005-11-09—Filed