FIELD: organic chemistry, nucleosides. SUBSTANCE: invention involves optimally substituted N6-oxa-, thia-, thioxa- and azacyclo-alkyl-substituted derivatives of adenosine that are selective agonists of adenosine receptors of type-I. These compounds are potentially useful agents for treatment of patients with cardiovascular diseases and diorders of the central nervous system. Invention describes novel derivatives of adenosine of the general formula (I) 
where R1 means monocyclic hetero-cyclic group containing from 3 to 15 atoms and at least one of that is taken among the group consisting of N, O and SO2 that can be mono- or poly-substituted with one or more substitutes taken among the group including oxo-group, hydroxyl, lower alkyl, substituted lower alkyl, acyl or carboxyl group where R1 does not mean monocyclic lactam or imide and where R1 does not contain epoxy-group. Invention describes also pharmaceutical composition and method of correction of electric disorders in mammal heart. EFFECT: new compounds indicated above, improved method of correction, valuable medicinal properties. 12 cl, 2 dwg, 2 tbl, 5 ex
