SUBSTITUTED 1,3-DIETHYL-8-VINYL-7-METHYL-3,7-DIHYDROPURINE-2,6-DIONES - ANTAGONISTS OF ADENOSINE A RECEPTOR AND USE THEREOF Russian patent published in 2013 - IPC C07D473/06 A61K31/522 A61P35/00 A61P31/04 A61P31/12 A61P37/00 A61P25/16 A61P25/24 

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds - substituted 1,3-diethyl-8-vinyl-7-methyl-3,7-dihydropurine-2,6-diones of general formula 1, which exhibit antagonist activity on adenosine A_2A receptors. The compounds can be used as an active source of a medicinal agent or adjuvant for pharmaceutical compositions and medicinal agents. The invention also relates to a method of inhibiting and a method of treating diseases of the central nervous system, oncological, viral and bacterial diseases which are mediated by adenosine A_2a receptor activity. In general formula 1 , where: Ar is 2,5-dimethoxyphenyl, 4-isobutoxy-3-methoxyphenyl, 3-phenoxyphenyl substituted with pyrrolidinyl, morpholinyl, piperidinyl, piperazinyl, C₁-C₅alkoxy group, amino group, optionally substituted with a mono- or di-C₁-C₅alkyl; 3-methylthiophen-2-yl, pyrazol-4-yl, substituted with C₁-C₅alkyl; 2,3-dihydro-benzo[1,4]dioxin-6-yl, optionally substituted with C₁-C₅alkoxycarbonyl, carbamoyl, which is optionally substituted with mono- or di-C₁-C₅alkyl, or carbonyl-piperazine, optionally substituted with C₁-C₅alkyl.

EFFECT: improved properties.

13 cl