TRIAZOLO[1,5-a]QUINOLINES AS LIGANDS OF ADENOSINE A3 RECEPTOR Russian patent published in 2013 - IPC C07D471/04 C07D215/58 C07F7/22 A61K31/4745 A61P11/06 A61P29/00 

FIELD: biotechnologies.

SUBSTANCE: new derivatives of triazolo[1,5-a]quinoline of general formula (I)

, where X means -NH-; R¹³-cyano; R¹ and R² mean H or methyl; R⁵-phenyl, possibly substituted, or 5- or 6-member heterocyclyl; R³ means phenyl or one atom of nitrogen containing 6-member heterocyclyl; R⁴ - one atom of nitrogen containing 6-member heterocyclyl or a group of the formula (a), , where R⁶ and R⁷ - independently mean C_3-6cycloalkyl or C_1-4alkyl; or a group of the formula (b) , where R⁸ and R⁹ mean C_1-4alkyl; Z - oxygen or a group -NR¹²-, where R¹² - hydrogen, C_1-4alkyl, C_3-6 cycloalkyl, benzyl, -CH₂-acetyl, -CH₂-CH₂-O-CH₂-CH₃ or acetyl; W means nitrogen atom or a group -CH-; m and o mean 2; p and r mean zero or 1; t means zero; methods of their production, new intermediate compounds of described methods of production, a pharmaceutical composition containing these compounds, and application of compounds of common formula (I) and their pharmaceutical acceptable salts as ligands of adenosine A3 receptor in treatment of different diseases.

EFFECT: improved properties of compounds.