FIELD: medicine.
SUBSTANCE: invention concerns medicine and is intended for cardiovascular surgery in stenting of arteries. In a stent coating containing a polymer material with an active antiproliferative substance, said polymer material presents a copolymer of butyric and valeric acids, while the active antiproliferative substance is rubomycinum. The amount of the copolymer of butyric and valeric acids per one stent is 2-15 mg/stent, while rubomycinum composes a polymer layer in amount 0.002-0.025 mg/stent.
EFFECT: creation of simpler stent coating expressing biocompatibility and haemocompatibility, with optimal physical-mechanical properties, and also slow bioresorbility in vivo without production of toxic products and negative reactions from a vascular wall while in service.
3 cl, 3 dwg, 1 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SURGICAL FIBRE, METHOD OF ITS PRODUCTION AND ARTICLES MADE FROM IT | 2010 |
|
RU2436595C1 |
| SURGICAL MATERIAL (VERSIONS) | 2010 |
|
RU2433836C1 |
| METHOD OF OBTAINING OF COPOLYMER OF 3-HYDROXYBUTYRATE, 3-HYDROXYVALERATE AND 4-HYDROXYBUTYRATE | 2014 |
|
RU2565815C1 |
| METHOD OF OBTAINING OF COPOLYMER OF 3-HYDROXYBUTYRATE AND 3-HYDROXYHEXANOATE | 2014 |
|
RU2565819C1 |
| BIOLOGICALLY ACTIVE POLYMERIC MEDICAL COMPOSITION (VERSION) | 2010 |
|
RU2447902C2 |
| HERBICIDAL LONG-ACTING COMPOSITION FOR USE IN SOIL | 2012 |
|
RU2494621C1 |
| METHOD OF PRODUCING MICROBIAL COPOLYMERS FORMED BY MONOMERS OF 3-HYDROXYBUTYRIC ACID AND 4-HYDROXYBUTYRIC ACID ACIDS | 2015 |
|
RU2582255C1 |
| Cupriavidus eutrophus VKPM B-10646 BACTERIA STRAIN - PRODUCER OF POLYHYDROXY ALKANOATES AND PRODUCTION METHOD THEREOF | 2010 |
|
RU2439143C1 |
| BIOLOGICALLY ACTIVE POLYMER MEDICAL COMPOSITION | 2023 |
|
RU2815508C1 |
| METHOD FOR MODIFYING SURFACE OF ENDOCARDIAL ELECTRODES | 2010 |
|
RU2452516C1 |
