FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine, namely a medical composition used for drug storage and delivery, particularly coatings for medical devices, self-contained films, cell cultivation matrixes, etc. The composition contains 3-hydroxybutyrate and 3-hydroxyvalerate (3-PHB/3-PHV) copolymer, and at least one biologically active substance selected from a group of antibiotics or nonsteroid anti-inflammatory preparations in the following proportions, wt %: 3-PHB/3-PHV copolymer 1-6; biologically active substance 1-5; solvent the rest. Additionally, the composition contains a surfactant or polyethylene glycol or gelatin. The composition is presented in the form of microparticles or film.
EFFECT: creation of the biologically active polymeric medical composition of wide spectrum of action and application showing biological compatibility and haematological compatibility, optimal physical-chemical properties, as well as an ability for slow biological resorption in vivo with making no toxic products and negative reactions in use.
18 cl, 8 dwg, 1 tbl
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Authors
Dates
2012-04-20—Published
2010-07-21—Filed