PYRROLE- OR IMIDAZOLE AMIDES FOR WEIGHT-REDUCING TREATMENT Russian patent published in 2010 - IPC C07D405/06 C07D405/14 C07D403/06 A61K31/4523 A61K31/4178 A61K31/4025 A61K31/5377 A61P3/00 

FIELD: chemistry.

SUBSTANCE: in formula I X is C-R⁶ or N, R¹ is hydrogen, R² is selected from a group comprising (lower)alkyl unsubstituted or substituted with one, two or three substitutes, independently selected from a group comprising hydroxy, (lower)alkoxy, fluoro(lower)alkyl, phenyl, C_3-8cycloalkyl and a 6-member saturated heterocyclic ring containing two heteroatoms selected from nitrogen and oxygen atoms, C_3-8cycloalkyl, unsubstituted or substituted hydroxyl, 5- or 6-member saturated heterocyclic ring containing one nitrogen atoms, where the said heterocyclic ring is unsubstituted or substituted hydroxy, fluoro(lower)alkyl, bicyclo[4.1.0]hept-7-yl, unsubstituted or condensed with a phenyl ring; and 4,7,7-trimethylbicyclo[2.2.1]hept-2-yl, substituted with one substituted independently selected from a group comprising hydroxy, (lower)alkoxy and (lower)acyloxy, R³ is a 5- or 6-member saturated heterocyclic ring containing one or two oxygen atoms, where the said heterocyclic ring is unsubstituted or substituted with one or two substitutes independently selected from a group comprising (lower)alkyl and alkoxycarbonyl, or condensed with a phenyl ring, or R² is a pyrrolidine ring which is unsubstituted or substituted with (lower)alkyl and alkoxycarbonyl. Values of the rest of the radicals are given in the formula of invention. The invention also relates to a pharmaceutical composition containing the disclosed compound as an active ingredient.

EFFECT: disclosed compounds have antagonistic activity towards cannabinoid receptors CB1 and can be used as therapeutically active substance for preparing medicinal agents with antagonistic activity towards cannabinoid receptors CB1.

20 cl, 74 ex