FIELD: medicine, pharmaceutics.
SUBSTANCE: there are presented: using a metabotropic glutamate receptor modulator (mGluR5 modulator) (-)-(3aR, 4S, 7aR)-4-hydroxy-4-meta-tolylethinyl-octahydro-indole-1-methyl carboxylate in a combination with at least one of: L-dopa or a dopa-decarboxylase inhibitor, a catechol-O-methyl transferase inhibitor, or a dopamine agonist, or in each case their pharmaceutically acceptable salt for preparing a therapeutic agent for treating, preventing or delaying the development of Parkinson's disease and/or a disorder related to Parkinson's disease, and a pharmaceutical composition with the above ingredients for the same application.
EFFECT: what is shown is a synergetic effect of the combination as compared with the response caused by administering L-dopa separately, and relieving dyskinesia.
8 cl, 7 dwg, 2 ex
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