BENZOPYRANES, INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT Russian patent published in 1998 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to benzopyranes of the formula (I) where X is O or NH; R, R¹ and R² - H or C₁-cyanoalkyl; R³ is (a) 6-membered heterocyclic ring containing 1 or 2 N atoms being yhis ring is bound with X through carbon atom in ring, optionally fused with benzene ring and optionally substituted with alkyl, halogen or oxo-group at condition that R³ is not -N-(C_1-6-alkyl)-pyridonyl group; (b) when X is NH then group (i) R⁴ or (c) when X is NH then group (j) R⁵; C_1-6 is phenyl substituted with 1 or 2 hydroxy-groups; R⁶ is SR⁵-alkyl; R⁷ is R⁸-OR⁵; is cyano-group; , or their pharmaceutically acceptable salts. Compounds of the formula (I) show capability to relax smooth muscles since they are able to open potassium channels in this tissue and can be used in medicine. EFFECT: improved method of synthesis, enhanced effectiveness. 22 cl, 1 tbl, 27 ex