BENZOPYRAN DERIVATIVE Russian patent published in 2009 - IPC C07D311/68 C07D311/70 A61K31/353 A61P9/06 

FIELD: chemistry.

SUBSTANCE: invention refers to the new benzopyran derivatives of formula (I) whereat X is NR⁶, R⁶ is hydrogen atom r C_1-4-alkyl group; Y is bond SO, SO₂; Z is C_1-4-alkyl group (whereat C_1-4-alkyl group can be arbitrary substituted with 1-5 atoms of halogen) or phenyl group (whereat phenyl group can be arbitrary substituted with C_1-4-alkyl group); W is hydrogen atom, halogen atom, hydroxy group, C_1-6-alkoxygroup, C_1-4-alkyl group, C_1-6-alkyl sulphonylamino group; R¹ and R² independently of each other represent C_1-3-alkyl group; R³ is hydrogen atom, hydroxy group or methoxy group; m is integer number from 0 to 4; n is integer number from 0 to 4; V is ordinary bond; R⁴ is hydrogen or C_1-6-alkyl group; and R⁵ is - hydrogen atom,- C_1-6-alkyl group,- C_3-8-cycloalkyl group or C_3-8-cycloalkenyl group or - C_6-14-aryl group (whereat every C_6-14-aryl group can be arbitrary substituted with 1-3 R¹² whereat R¹² is halogen atom) and pharmaceutical composition thereof.

EFFECT: compounds are applicable as antiarrhythmic drug.

27 cl, 60 tbl, 20 ex