4-PHENYLPYRIMIDINE-2-CARBONITRILE DERIVATIVES Russian patent published in 2010 - IPC C07D239/28 C07D403/06 C07D403/12 C07D413/06 C07D413/12 A61K31/505 A61K31/506 A61P19/10

Abstract RU 2382773 C2

FIELD: chemistry.

SUBSTANCE: invention relates to novel 4-phenylpyrimidine-2-carbonitrile of formula

(values of R, R¹, R² are given in the formula of invention) or their pharmaceutically acceptable salts which have inhibition properties towards catepsin K and catepsin S. The invention also relates to use of derivatives of formula I for treating catepsin K and catepsin S related disorders, as well as to a pharmaceutical composition containing the said derivative.

EFFECT: improved properties of derivatives.

9 cl, 151 ex

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RU 2 382 773 C2

Authors

Tsaj Tszjatsjan

Rankovich Zoran

Moir Dzhennifer Khelen

Dates

2010-02-27—Published

2005-06-09—Filed