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(19)

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2 666 538

(13)

(51)

IPC

C07D401/04(2006-01-01)

C07D473/00(2006-01-01)

C07D487/04(2006-01-01)

A61K31/52(2006-01-01)

A61K31/506(2006-01-01)

A61K31/519(2006-01-01)

A61K31/53(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2015106787, 2013-07-24

(24)

Start date

2013-07-24

(22)

Actual filing date

2013-07-24

(45)

Published

2018-09-11

(72)

Inventor

Braska Mariya GabriellaBindi SimonaKaldarelli MarinaNezi MarchellaOrrenius Sten KristianPantseri Akille

(73)

Holder

Nerviano Medikal Sajensiz S.R.L.

SUBSTITUTED PYRROLES ACTIVE AS KINASES INHIBITORS Russian patent published in 2018 - IPC C07D401/04 C07D473/00 C07D487/04 A61K31/52 A61K31/506 A61K31/519 A61K31/53 A61P35/00

Abstract RU 2666538 C2

FIELD: chemistry.

SUBSTANCE: invention relates to substituted pyrrole compounds of formula (Ia), (Ib) or (Id) which modulate the activity of protein kinases and therefore are useful in treating diseases caused by dysregulated protein kinase activity, in particular JAK family kinases.

R4 :

EFFECT: invention also relates to methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and the use of these compounds for cancer treatment.

8 cl, 3 tbl, 15 ex

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RU 2 666 538 C2

Authors

Braska Mariya Gabriella

Bindi Simona

Kaldarelli Marina

Nezi Marchella

Orrenius Sten Kristian

Pantseri Akille

Dates

2018-09-11—Published

2013-07-24—Filed