FIELD: chemistry.
SUBSTANCE: described are compounds of formula (I)
Values of radicals R1-R6 are given in the formula of invention. The compounds inhibit protein kinase MEK1/2. Also described is a pharmaceutical composition for administration in diseases mediated by MEK1/2.
EFFECT: compounds are highly efficient.
16 cl, 27 ex
Title | Year | Author | Number |
---|---|---|---|
SUBSTITUTED HYDANTOINS FOR TREATING CANCER | 2005 |
|
RU2393156C2 |
METHOD OF TREATMENT OR PROPHYLAXIS OF MAMMALS AND HUMAN WITH VOMITING USING SOME QUINUCLIDINE, PIPERIDINE, AZANORBORNANE, ETHYLENEDIAMINE DERIVATIVES AND RELATED COMPOUNDS | 1994 |
|
RU2135179C1 |
SULTAM DERIVATIVES | 2010 |
|
RU2565752C2 |
BENZIMIDAZOLE DERIVATIVES, SYNTHESIS METHODS THEREOF, USE THEREOF AS FARNESOID X RECEPTOR (FXR) AGONIST AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID DERIVATIVES | 2007 |
|
RU2424233C2 |
SUBSTITUTED N-(INDOLE-2-CARBONYL)-BETA-ALANYLAMIDES AND THEIR DERIVATIVES, METHOD OF TREATING GLYCOGENPHOSPHORYLAZO-DEPENDENT DISEASES, METHOD FOR PREVENTING ISCHEMIC MYOCARDIUM DAMAGES, AND PHARMACEUTICAL COMPOSITIONS | 1996 |
|
RU2159613C2 |
NEW IMIDE DERIVATIVES AND THEIR USE AS DRUG | 2016 |
|
RU2772429C2 |
POLYCYCLIC AGENTS FOR TREATING RESPIRATORY SYNCYTIAL VIRAL INFECTIONS | 2004 |
|
RU2422444C2 |
DERIVATIVES OF 7-ARYL-3,9-DIAZABICYCLO(3,3,1)NON-6-ENE-RHENIN INHIBITORS | 2003 |
|
RU2343153C2 |
KYNURENINE-3-MONOOXYGENASE INHIBITORS | 2009 |
|
RU2523448C2 |
N-(1-(1-BENZYL-4-PHENYL-1H-IMIDAZOL-2-YL)-2,2-DIMETHYLPROPYL)-BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS KINESIN SPINDLE PROTEIN (KSP) INHIBITORS FOR TREATING CANCER | 2005 |
|
RU2427572C2 |
Authors
Dates
2010-03-10—Published
2005-08-09—Filed