NEW IMIDE DERIVATIVES AND THEIR USE AS DRUG Russian patent published in 2022 - IPC C07D233/78 C07D401/10 C07D401/12 C07D401/14 C07D403/10 C07D403/14 C07D405/14 C07D409/14 C07D413/14 C07D417/14 C07D471/04 C07D498/04 C07D513/04 A61K31/4178 A61K31/437 A61K31/4439 A61K31/454 A61K31/4545 A61K31/496 A61K31/497 A61K31/501 A61P1/04 A61P19/02 A61P25/00 A61P29/00 A61P37/06 A61P43/00 

FIELD: organic chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, namely to an imide derivative of the formula (I) or to its pharmacologically acceptable salt, where A is 5-element heteroarylene containing 1 sulfur atom, or phenylene, where phenylene is optionally substituted with one or 2 the same or different substituents selected from a halogen atom; a hydroxyl group and C₁-C₆ alkyl, the right bond is bound to carbonyl, and the left bond is bound to quaternary carbon bound to R²; R^1a, R^1b and R^1c are the same or different, and each is a hydrogen atom; a hydroxyl group; cyano; C₁-C₆ alkyl optionally substituted with one substituent selected from C₁-C₆ alkoxy; or two of R^1a, R^1b and R^1c combine to form C₃-C₆ cycloalkyl; R² is C₁-C₆ alkyl optionally substituted with one or 2 or 3 the same or different substituents selected from a halogen atom and C₁-C₆ alkoxy; C₃-C₆ cycloalkyl optionally substituted with C₁-C₆ alkoxy; a saturated non-aromatic heterocyclic group containing 1 oxygen atom and having 6 atoms making up a ring; or C₆-C₁₀ aryl; R³ is a hydrogen atom or C₁-C₆ alkyl; W is -N(R^x)-, where R^x is a hydrogen atom or C₁-C₆ alkyl; m+n is 0, 1 or 2; X is a carbon atom or a nitrogen atom; V is a bond; carbonyl; an oxygen atom; or -N(R^Y)-, where R^Y is a hydrogen atom, and Y is a 6-element ring group, a 5-element ring group substituted with the 6-element ring group, or a condensed ring group of a 5-element ring and a 6-element ring, where the 5-element ring and the 5-element ring group contain 1-4 atoms selected from a nitrogen atom, an oxygen atom and a sulfur atom, and the rest consists of a carbon atom, the 6-element ring and the 6-element ring group contain 0-2 nitrogen atoms, and the rest consists of a carbon atom, and these ring groups are optionally substituted with one or 2 or 3 the same or different substituents selected from a halogen atom; C₁-C₆ alkyl optionally substituted with 3 halogen atoms; and C₃-C₆ cycloalkyl. The invention also relates to specific compounds, a pharmaceutical composition, a remedy for suppressing MMR-9 products and a drug based on a compound of the formula (I), as well as a method for the treatment and/or prevention of the specified diseases.

EFFECT: new heterocyclic compounds are obtained that have an inhibitory effect on MMP-9 products and that are useful as a drug for the prevention and/or treatment of autoimmune diseases, such as rheumatoid arthritis and the like, inflammatory bowel diseases (ulcerative colitis, Crohn’s disease) or osteoarthritis.

22 cl, 6 tbl, 358 ex