PHARMACEUTICAL COMPOSITIONS CONTAINING NEP-INHIBITORS, INHIBITORS OF ENDOGENOUS ENDOTHELIN-PRODUCING SYSTEM AND AT-RECEPTOR ANTAGONISTS Russian patent published in 2010 - IPC A61K45/06 A61K31/55 A61K31/4184 A61K31/4178 A61P9/00 

FIELD: medicine.

SUBSTANCE: invention refers to a pharmaceutical composition for prevention or treatment of cardiovascular diseases, containing each of the following compounds in pharmacologically effective amount a) NEP inhibitor, b) inhibitor of endogenous endothelin-producing system and c) AT₁-receptor antagonist chosen from the group, including candesartan, eprosartan and lossartan, where a subcombination of neutral endopeptidase inhibitor (a) and inhibitor of endogenous endothelin-producing system (b) is daglutryl. There is also disclosed application of daglutryl in combination with AT₁-receptor antagonist chosen from the group including candesartan, eprosartan and lossartan to prepare a medicine for prevention or treatment of a cardiovascular disease in mammals and human.

EFFECT: composition under the invention exhibits the synergetic effect and a favorable safety profile.

8 cl, 3 tbl, 1 ex