NEPRILYSIN INHIBITORS Russian patent published in 2018 - IPC C07D231/14 C07D231/20 C07D249/04 C07D261/18 C07D263/38 C07D405/12 A61K31/415 A61K31/4192 A61K31/42 A61K31/421 A61P9/04 A61P9/12 A61P13/12 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula IIa or IIb

, in which a) R^a and R^b are H; and R² is H; and R⁷ is -CH₂CF₂CH₃ or -CH₂CF₂CF₃; or R² is -C_1-6alkyl or -C(O)-C_1-6alkyl and R⁷ is H; or b) R^a is selected from -CH₃, -OCH₃ and Cl and R^b is H; or R^a is selected from H, -CH₃, Cl and F and R^b is Cl; or R^a is H and R^b is selected from -CH₃ and -CN; and R² is selected from -C_1-6alkyl and -(CH₂)_2-3OH and R⁷ is selected from H and -C_1-6alkyl; or c) R^a is H and R^b is F; or R^a is F and R^b is H; R² is selected from -C_1-6alkyl and -(CH₂)_2-3OH; and R⁷ is selected from H and -C_1--6alkyl. Invention also relates to a compound of formula III, a compound of formula V, to an individual compound, to a compound of formula VIa or VIb, to a compound of formula VIIa or VIIb, to a pharmaceutical composition, having neprilysin (NEP) inhibition activity, to the use of the compound.

EFFECT: technical result is obtaining novel compounds having neprilysin (NEP) inhibition activity and which can be used in the treatment of hypertension, heart failure or kidney disease.

13 cl, 8 ex