NEPRILYSIN INHIBITORS Russian patent published in 2018 - IPC C07D231/18 C07D231/14 C07D231/20 C07D249/04 C07D249/12 C07D249/18 C07D253/08 C07D257/04 C07D261/18 C07D401/04 C07D405/04 C07D405/14 A61K31/4192 A61K31/415 A61K31/4155 A61K31/4439 A61K31/42 A61K31/4196 C07F9/6503 A61K31/675 A61P9/12 A61P13/12 

Abstract RU 2663618 C2

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula XII, where the values of Ra, Rb, R2, R7 and X are as defined in the claims, or a pharmaceutically acceptable salt thereof. .

EFFECT: compound of the invention has neprilysin (NEP) inhibition activity and is intended for the preparation of a medicament for treating hypertension, heart failure or kidney disease.

28 cl, 11 ex

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RU 2 663 618 C2

Authors

Khyuz Adam

Fleri Melissa

Dates

2018-08-07Published

2013-06-06Filed